GW-2580, CSF-1 Receptor Inhibitor

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Product Code: 9776
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A cFMS kinase activity inhibitor.

Chemical Name: 5-(3-Methoxy-4-((4-methoxybenzyl)oxy)benzyl)-pyrimidine-2,4-diamine

Biological Activity:
Biological Activity	cFMS Receptor Tyrosine Kinase Inhibitor is a selective cell-permeable diaminopyrimidine compound that inhibits colony-stimulating factor (CSF)-1 resulting in suppression of monocyte growth and bone degradation in vitro and inhibits CSF-1 signaling through cFMS kinase. In addition, studies show that cFMS Receptor Tyrosine Kinase Inhibitor inhibits nuclear factor B ligand, a molecule responsible for osteoclast differentiation. Further studies confirmed that the inhibitor partially inhibits thioglycolate-induced cell influx into the peritoneal cavity and completely suppresses the growth of CSF-1-dependent tumor cells and M-NFS-60 myeloid cells.
Technical Data:
M.W.	366.4
Formula:	C<sub>20</sub>H<sub>22</sub>N<sub>4</sub>O<sub>3</sub>
Solubility:	Soluble in DMSO (25 mg/ml).
Storage:	Store at 4° C
CAS No:	870483-87-7
References:
References	1. Conway, J.G., et al. 2005. Proc. Natl. Acad. Sci. U.S.A. 102: 16078-16083. PMID: 16249345 2. Conway, J.G., et al. 2008. J. Pharmacol. Exp. Ther. 326: 41-50. PMID: 18434589

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