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Danusertib

Danusertib

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Product Code: 3108
Availability: In Stock
$398.00
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Danusertib (PHA-739358) is an Aurora kinase inhibitor for Aurora A/B/C with IC50 of 13 nM/79 nM/61 nM, modestly potent to Abl, TrkA, c-RET and FGFR1, and less potent to Lck, VEGFR2/3, c-Kit, CDK2, etc. Phase 2.

Chemical Name

R)-N-(5-(2-methoxy-2-phenylacetyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)-4-(4-methylpiperazin-1-yl)benzamide

Inhibitors Apoptosis c-RET Danusertib 827318-97-8
Biological Activity:
Biological Activity Danusertib (PHA-739358) is an Aurora kinase inhibitor for Aurora A/B/C with IC50 of 13 nM/79 nM/61 nM, modestly potent to Abl, TrkA, c-RET and FGFR1, and less potent to Lck, VEGFR2/3, c-Kit, CDK2, etc. Phase 2.
Technical Data:
M.W. 474.55
Formula: C<sub>26</sub>H<sub>30</sub>N<sub>6</sub>O<sub>3</sub>
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 827318-97-8
References:
References Carpinelli P, et al. Mol Cancer Ther, 2007, 12 Pt 1, 3158-3168. Fancelli D, et al. J Med Chem, 2006, 49(24), 7247-7251. Gontarewicz A, et al. Blood, 2008, 111(8), 4355-4364.

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