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Regorafenib

Regorafenib

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Product Code: 3286
Availability: In Stock
$259.00
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Regorafenib (BAY 73-4506) is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM, respectively.

Chemical Name:  1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2-fluoro-4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)urea

Inhibitors Protein Tyrosine Kinase c-RET Regorafenib 755037-03-7
Biological Activity:
Biological Activity Regorafenib (BAY 73-4506) is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM, respectively.
Technical Data:
M.W. 482.82
Formula: <p>C<sub>21</sub>H<sub>15</sub>ClF<sub>4</sub>N<sub>4</sub>O<sub>3</sub></p>
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 755037-03-7
References:
References Wilhelm SM, et al. Int J Cancer, 2011, 129(1), 245-255. Heng DY, et al. Ther Adv Med Oncol, 2010, 2(1), 39-49. Carr BI, et al. J Cell Physiol, 2013, 228(2), 292-297.

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