TAE684

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Product Code: 3235
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TAE684 is a potent and selective ALK inhibitor with IC50 of 3 nM, 100-fold more sensitive for ALK than InsR.

Chemical Name:
5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine

Biological Activity:
Biological Activity	TAE684 is a potent and selective ALK inhibitor with IC50 of 3 nM, 100-fold more sensitive for ALK than InsR.
Technical Data:
M.W.	614.2
Formula:	C<sub>30</sub>H<sub>40</sub>ClN<sub>7</sub>O<sub>3</sub>S
Solubility:	DMSO
Purity:	98%
Storage:	-20℃
CAS No:	761439-42-3
References:
References	Galkin AV, et al. Proc Natl Acad Sci U S A, 2007, 104(1), 270-275. Katayama R, et al. Proc Natl Acad Sci U S A, 2011, 108(18), 7535-7540. Sch?nherr C, et al, Biochem J, 2011, 440(3), 405-413.

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