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PD173074

PD173074

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Product Code: 3314
Availability: In Stock
$146.00
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PD173074 is a potent FGFR1 inhibitor with IC50 of ~25 nM and also inhibits VEGFR2 with IC50 of 100-200 nM, ~1000-fold selective for FGFR1 than PDGFR and c-Src.

Chemical Name 1-tert-butyl-3-(2-(4-(diethylamino)butylamino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea

Inhibitors Protein Tyrosine Kinase FGFR PD173074 219580-11-7
Biological Activity:
Biological Activity PD173074 is a potent FGFR1 inhibitor with IC50 of ~25 nM and also inhibits VEGFR2 with IC50 of 100-200 nM, ~1000-fold selective for FGFR1 than PDGFR and c-Src.
Technical Data:
M.W. 523.67
Formula: <p>C<sub>28</sub>H<sub>41</sub>N<sub>7</sub>O<sub>3</sub></p>
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 219580-11-7
References:
References Mohammadi M, et al. EMBO J, 1998, 17(20), 5896-5904. Skaper SD, et al. J Neurochem, 2000, 75(4), 1520-1527. Bansal R, et al. J Neurosci Res, 2003, 74(4), 486-493. Trudel S, et al. Blood, 2004, 103(9), 3521-3528. Pardo OE, et al. Cancer Res, 2009, 69(22), 8645-8651. Byron SA, et al. Int J Gynecol Cancer, 2012, 22(9), 1517-1526.

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