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BMS-536924

BMS-536924

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Product Code: 3070
Availability: In Stock
$398.00
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BMS-536924 is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for Mek, Fak, and Lck with very little activity for Akt1, MAPK1/2.

Chemical Name: 4-[[(2S)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]-3-[7-methyl-5-(4-morpholinyl)-1H-benzimidazol-2-yl]-2(1H)-pyridinone

Inhibitors Protein Tyrosine Kinase IGF-1R BMS-536924 468740-43-4
Biological Activity:
Biological Activity BMS-536924 is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for Mek, Fak, and Lck with very little activity for Akt1, MAPK1/2.
Technical Data:
M.W. 479.96
Formula: <p>C<sub>25</sub>H<sub>26</sub>ClN<sub>5</sub>O<sub>3</sub></p>
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 468740-43-4
References:
References Wittman M, et al. J Med Chem, 2005, 48(18), 5639-5643 Litzenburger BC, et al. Clin Cancer Res, 2009, 15(1), 226-237 Huang F, et al. Cancer Res, 2009, 69(1), 161-170 Hirokazu Ohashi, et al. Cancer Sci, 2012, 103(2), 252-261 Haluska P, et al, Mol Cancer THer, 2008, 7(9), 2589-2598. Huang F, et al, Cancer Res, 2009, 69(1), 161-170.

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