NVP-AEW541

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Product Code: 3338
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NVP-AEW541 is a potent inhibitor of IGF-1R with IC50 of 86 nM, 27-fold greater selectivity for IGF-1R than InsR.

Chemical Name 7-((1s,3s)-3-(azetidin-1-ylmethyl)cyclobutyl)-5-(3-(benzyloxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Biological Activity:
Biological Activity	NVP-AEW541 is a potent inhibitor of IGF-1R with IC50 of 86 nM, 27-fold greater selectivity for IGF-1R than InsR.
Technical Data:
M.W.	439.55
Formula:	<p>C<sub>27</sub>H<sub>29</sub>N<sub>5</sub>O</p>
Solubility:	DMSO
Purity:	98%
Storage:	-20℃
CAS No:	475489-16-8
References:
References	García-Echeverría C, et al. Cancer Cell. 2004, 5(3), 231- Scotlandi K, et al. Cancer Res, 2005, 65(9), 3868-3876. Tanno B, et al. Clin Cancer Res. 2006, 12(22), 6772-6780. Gariboldi MB, et al. Biochem Pharmacol, 2010, 80(4), 455-462. Isebaert SF, et al. Int J Radiat Oncol Biol Phys, 2011, 81(1), 239-247.

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