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PHA-665752

PHA-665752

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Product Code: 3355
Availability: In Stock
$146.00
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PHA-665752 is a potent, selective and ATP-competitive c-Met inhibitor with IC50 of 9 nM, >50-fold selectivity for c-Met than RTKs or STKs.

Chemical name(R,Z)-5-(2,6-dichlorobenzylsulfonyl)-3-((3,5-dimethyl-4-(2-(pyrrolidin-1-ylmethyl)pyrrolidine-1-carbonyl)-1H-pyrrol-2-yl)methylene)indolin-2-one

Inhibitors Protein Tyrosine Kinase c-Met PHA-665752 477575-56-7
Biological Activity:
Biological Activity PHA-665752 is a potent, selective and ATP-competitive c-Met inhibitor with IC50 of 9 nM, >50-fold selectivity for c-Met than RTKs or STKs.
Technical Data:
M.W. 641.61
Formula: <p>C<sub>32</sub>H<sub>34</sub>Cl<sub>2</sub>N<sub>4</sub>O<sub>4</sub>S</p>
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 477575-56-7
References:
References Christensen JG, et al. Cancer Res, 2003, 63(21), 7345-7355. Ma PC, et al. Clin Cancer Res, 2005, 11(6), 2312-2319. Puri N, et al. Cancer Res, 2007, 67(8), 3529-3534.

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