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Foretinib

Foretinib

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Product Code: 3148
Availability: In Stock
$1,091.00
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Foretinib (GSK1363089) is an ATP-competitive inhibitor of HGFR and VEGFR, mostly for Met and KDR with IC50 of 0.4 nM and 0.9 nM. Less potent against Ron, Flt-1/3/4, Kit, PDGFRα/β and Tie-2, and little activity to FGFR1 and EGFR. Phase 2.

Chemical Name :

N-(3-fluoro-4-(6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yloxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Inhibitors Protein Tyrosine Kinase c-Met Foretinib 849217-64-7
Biological Activity:
Biological Activity Foretinib (GSK1363089) is an ATP-competitive inhibitor of HGFR and VEGFR, mostly for Met and KDR with IC50 of 0.4 nM and 0.9 nM. Less potent against Ron, Flt-1/3/4, Kit, PDGFRα/β and Tie-2, and little activity to FGFR1 and EGFR. Phase 2.
Technical Data:
M.W. 632.65
Formula: C<sub>34</sub>H<sub>34</sub>F<sub>2</sub>N<sub>4</sub>O<sub>6</sub>
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 849217-64-7
References:
References Qian F, et al. Cancer Res, 2009, 69(20), 8009-8016. Kataoka Y, et al. Invest New Drugs, 2011. Eder JP, et al. Clin Cancer Res, 2010, 16(13), 3507-3516.

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