Crizotinib

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Product Code: 3102
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PF-2341066 (Crizotinib) is a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nM, respectivley.

Chemical Name

3-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine

Biological Activity:
Biological Activity	PF-2341066 (Crizotinib) is a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nM, respectivley.
Technical Data:
M.W.	450.34
Formula:	C<sub>21</sub>H<sub>22</sub>Cl<sub>2</sub>FN<sub>5</sub>O
Solubility:	DMSO
Purity:	98%
Storage:	-20℃
CAS No:	877399-52-5
References:
References	Zou HY, et al. Cancer Res. 2007, 67(9), 4408-4417. Christensen JG, et al. Mol Cancer Ther. 2007, 6(12 Pt 1), 3314-3322. Sampson ER, et al. J Bone Miner Res. 2011, 26(6), 1283-1294. Cullinane C, et al. J Nucl Med. 2011, 52(8), 1261-1267. Gong HC, et al. Int J Proteomics. 2011, 2011, 215496.

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