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Crenolanib

Crenolanib

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Product Code: 3101
Availability: In Stock
$398.00
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Crenolanib (CP-868596) is a potent and selective inhibitor of PDGFRα/β with Kd of 2.1 nM/3.2 nM, also potently inhibits FLT3, sensitive to D842V mutation not V561D mutation, >100-fold more selective for PDGFR than c-Kit, VEGFR-2, TIE-2, FGFR-2, EGFR, erbB2, and Src.

Chemical Name

1-(2-(5-((3-methyloxetan-3-yl)methoxy)-1H-benzo[d]imidazol-1-yl)quinolin-8-yl)piperidin-4-amine

Inhibitors Protein Tyrosine Kinase PDGFR Crenolanib 670220-88-9
Biological Activity:
Biological Activity Crenolanib (CP-868596) is a potent and selective inhibitor of PDGFRα/β with Kd of 2.1 nM/3.2 nM, also potently inhibits FLT3, sensitive to D842V mutation not V561D mutation, >100-fold more selective for PDGFR than c-Kit, VEGFR-2, TIE-2, FGFR-2, EGFR, erbB2, and Src.
Technical Data:
M.W. 443.54
Formula: C<sub>26</sub>H<sub>29</sub>N<sub>5</sub>O<sub>2</sub>
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 670220-88-9
References:
References Heinrich MC, et al, Clin Cancer Res, 2012, Jun 27. Heinrich M, et al, AACR, 2011, Abstract 3586.

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