Imatinib

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Product Code: 3428
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Imatinib is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM, respectively.

Chemical name: N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)-4-[(4-methylpiperazin-1-yl)methyl]benzamide

Biological Activity:
Biological Activity	Imatinib is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM, respectively.
Technical Data:
M.W.	493.6
Formula:	<p>C<sub>29</sub>H<sub>31</sub>N<sub>7</sub>O</p>
Solubility:	DMSO
Purity:
Storage:	6 months-80℃in DMSO
CAS No:	152459-95-5
References:
References	Buchdunger E, et al. Proc Natl Acad Sci USA. 1995, 92(7), 2558–2562. Heinrich MC, et al. Blood. 2000, 96(3), 925-932. Yao JC, et al. Clin Cancer Res. 2007, 13(1), 234-240. Zheng F, et al. Med Oncol, 2012, 29(3), 2127-2135. Decaudin D, et al. Int J Cancer. 2005, 113(5), 849-856. Ballinger ML, et al. J Cell Mol Med. 2010,14(6B), 1408-1418.

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