PD-153035

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Product Code: 9777
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An extremely potent and specific inhibitor of the tyrosine kinase activity of EGFR.

Chemical Name: 4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline

Biological Activity:
Biological Activity	PD 153035 is an extremely potent and specific inhibitor of the tyrosine kinase activity of the EGFR (epidermal growth factor receptor; IC50 = 25 pM; Kι = 6 pM). PD 153035 rapidly suppresses auto-phosphorylation of EGFR at low nanomolar concentrations in fibroblasts or in human epidermoid carcinoma cells. PD 153035 also selectively blocks EGF-mediated cellular processes including mitogenesis, early gene expression, and oncogenic transformation.
Technical Data:
M.W.	360.21
Formula:	C<sub>16</sub>H<sub>14</sub>BrN<sub>3</sub>O<sub>2</sub>
Solubility:	Soluble in DMSO (5 mg/ml).
Storage:	Store at -20° C
CAS No:	153436-54-5
References:
References	1. Fry, D.W., et al. 1994. Science. 265: 1093-1095. PMID: 8066447 2. Bridges, A.J., et al. 1996. J. Med. Chem. 39: 267-276. PMID: 8568816

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