Tyrphostin AG1433

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Product Code: 9788
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A potent, cell-permeable, reversible, and specific inhibitor of the PDGF-β receptor kinase.

Chemical Name: 2-(3,4-Dihydroxyphenyl)-6,7-dimethylquinoxaline, SU 1433

Biological Activity:
Biological Activity	A potent, cell-permeable, reversible, and specific inhibitor of the PDGF-β receptor kinase (IC50 = 5.0 µM) and of KDR/Flk-1/VEGF Receptor 2 (IC50 = 9.3 µM). Also acts as an angiogenesis inhibitor.
Technical Data:
M.W.	266.3
Formula:	C<sub>16</sub>H<sub>14</sub>N<sub>2</sub>O<sub>2</sub>
Solubility:	DMSO
CAS No:	168836-03-1
References:
References	1. Strawn, L.M., et al. 1996. Cancer Res. 56: 3540-3545. PMID: 8758924 2. Kroll, J., et al. 1997. J. Biol. Chem. 272: 32521-32527. PMID: 9405464

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