Dalcetrapib (JTT-705, RO4607381)

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Product Code: 3105
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Dalcetrapib (JTT-705) is a rhCETP inhibitor with IC50 of 0.2 μM that increases the plasma HDL cholesterol. Phase 3.

Chemical Name:

S-2-(1-(2-ethylbutyl)cyclohexanecarboxamido)phenyl 2-methylpropanethioate

Biological Activity:
Biological Activity	Dalcetrapib (JTT-705) is a rhCETP inhibitor with IC50 of 0.2 μM that increases the plasma HDL cholesterol. Phase 3.
Technical Data:
M.W.	389.59
Formula:	C<sub>23</sub>H<sub>35</sub>NO<sub>2</sub>S
Solubility:	DMSO
Purity:	98%
Storage:	-20℃
CAS No:	211513-37-0
References:
References	Niesor EJ, et al. J Lipid Res. 2010, 51(12), 3443-3454. Shinkai H, et al. J Med Chem. 2000, 43(19), 3566-3572. Huang Z, et al. Am J Physiol Endocrinol Metab. 2003, 284(6), E1210-E1219. Zhang B, et al. Arterioscler Thromb Vasc Biol. 2004, 24(10), 1910-1915. Derks M, et al. Br J Clin Pharmacol. 2010, 70(6), 825-833.

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