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Tipifarnib

Tipifarnib

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Product Code: 3216
Availability: In Stock
$599.00
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Tipifarnib (R115777) is a potent and specific farnesyltransferase (FTase) inhibitor with IC50 of 0.6 nM, its anti-proliferative effects are most prominent in H-ras or N-ras mutant cells. Phase 3.

Chemical Name:
(R)-6-(amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-chlorophenyl)-1-methylquinolin-2(1H)-one

Inhibitors Metabolism Transferase Tipifarnib 192185-72-1
Biological Activity:
Biological Activity Tipifarnib (R115777) is a potent and specific farnesyltransferase (FTase) inhibitor with IC50 of 0.6 nM, its anti-proliferative effects are most prominent in H-ras or N-ras mutant cells. Phase 3.
Technical Data:
M.W. 489.4
Formula: C<sub>27</sub>H<sub>22</sub>Cl<sub>2</sub>N<sub>4</sub>O
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 192185-72-1
References:
References Margolin KA, et al. Clin Cancer Res. 2012, 18(4), 1129-1137. Bai F, et al. Cancer Immunol Immunother. 2012, 61(4), 523-533. Kotsianidis I, et al. Acta Haematol. 2008, 120(1), 51-56. Martin LA, et al. Mol Cancer Ther. 2007, 6(9), 2458-2467. Krzykowska-Petitjean K, et al. J Cancer Res Clin Oncol. 2012, 138(3), 537-544. End DW, et al. Cancer Res. 2001, 61(1), 131-137.

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