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LDE225

LDE225

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Product Code: 3402
Availability: In Stock
$335.00
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LDE225 (NVP-LDE225) is a Smoothened (Smo) antagonist, inhibiting Hedgehog (Hh) signaling withIC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively. Phase 3.

Chemical Name [1,1'-Biphenyl]-3-carboxamide, N-[6-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-3-pyridinyl]-2-methyl-4'-(trifluoromethoxy)-, rel-

Inhibitors GPCR & G Protein Hedgehog/Smoothened LDE225 956697-53-3
Biological Activity:
Biological Activity LDE225 (NVP-LDE225) is a Smoothened (Smo) antagonist, inhibiting Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively. Phase 3.
Technical Data:
M.W. 485.5
Formula: <p>C<sub>26</sub>H<sub>26</sub>F<sub>3</sub>N<sub>3</sub>O<sub>3</sub></p>
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 956697-53-3
References:
References Pan SF, et al. ACS Med. Chem. Lett., 2010, 1 (3), 130–134. Fendrich V, et al. Ann Surg, 2011, 254(5), 818-23. Tauchi T, et al. Arthritis Res Ther, 2012, 14(Suppl 1), O43.

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