Vismodegib

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Product Code: 3188
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Vismodegib (GDC-0449) is a potent, novel and specific hedgehog inhibitor with IC50 of 3 nM and also inhibits P-gp with IC50 of 3.0 μM.

Chemical Name:
2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide

Biological Activity:
Biological Activity	Vismodegib (GDC-0449) is a potent, novel and specific hedgehog inhibitor with IC50 of 3 nM and also inhibits P-gp with IC50 of 3.0 μM.
Technical Data:
M.W.	421.3
Formula:	C<sub>19</sub>H<sub>14</sub>Cl<sub>2</sub>N<sub>2</sub>O<sub>3</sub>S
Solubility:	DMSO
Purity:	98%
Storage:	-20℃
CAS No:	879085-55-9
References:
References	Scales SJ, et al. Trends Pharmacol Sci. 2009, 30(6), 303-312. Zhang Y, et al. Neoplasia. 2009, 11(1), 96-101. Tian F, et al. Anticancer Res. 2012, 32(1), 89-94. Wong H, et al. Clin Cancer Res. 2011, 17(14), 4682-4692.

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