SC-560

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Product Code: 9794
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A highly potent and selective inhibitor of Cox-1.

Chemical Name: 5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-trifluoromethyl pyrazole

Biological Activity:
Biological Activity	SC 560 is reported to be a Cox-1 and Cox-2 inhibitor, and is highly selective for Cox-1 (IC50 of 0.009 μM) over Cox-2 (IC50 of 6.3 μM). SC 560 also inhibits UTP-stimulated and basal cAMP levels. Cox-1 is shown to catalyze the conversion of Arachidonic Acid into PGH2 (Prostaglandin H2), which is the precursor of thromboxanes and other prostaglandins, therefore SC 560 also suppresses TXB2 (Thromboxane B2) and PGE2 (Prostaglandin E2) production. SC 560 also displays the ability to induce cell growth inhibition by causing cell cycle arrest at the G1 phase. Mechanistic studies show that SC 560 causes apoptosis of cells by eliciting reactive oxygen species and simultaneously decreasing the levels of anti-apoptotic proteins XIAP and survivin. Additional experiments suggest that SC 560 also activates caspase-3 and caspase-7 which results in apoptosis of cells.
Technical Data:
M.W.	352.7
Formula:	C<sub>17</sub>H<sub>12</sub>ClF<sub>3</sub>N<sub>2O</sub>
Solubility:	Soluble in DMSO (200 mg/ml), ethanol (~22 mg/ml), DMF (~150 mg/ml)
Storage:	Store at -20° C
CAS No:	188817-13-2
Certificate of Analysis:
Certificate of Analysis
References:
References	1. Smith, C.J., et al. 1998. Proc. Natl. Acad. Sci. U.S.A. 95: 13313-13318. PMID: 9789085 2. Ostrom, R.S., et al. 2001. Am. J. Physiol. Cell Physiol. 281: 524-531. PMID: 11443051 3. Lee, E., et al. 2006. Exp. Mol. Med. 38: 325-331. PMID: 16819292 4. Lampiasi, N., et al. 2006. Int. J. Mol. Med. 17: 245-252. PMID: 16391822

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SC-560

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