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JNJ-26854165

JNJ-26854165

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Product Code: 3414
Availability: In Stock
$461.00
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JNJ-26854165 acts as a HDM2 ubiquitin ligase antagonist and also induces early apoptosis in p53 wild-type cells, inhibits cellular proliferation followed by delayed apoptosis in the absence of functional p53. Phase 1.

Chemical Name N1-(2-(1H-indol-3-yl)ethyl)-N4-(pyridin-4-yl)benzene-1,4-diamine

Inhibitors Ubiquitin E3 Ligase JNJ-26854165 881202-45-5
Biological Activity:
Biological Activity JNJ-26854165 acts as a HDM2 ubiquitin ligase antagonist and also induces early apoptosis in p53 wild-type cells, inhibits cellular proliferation followed by delayed apoptosis in the absence of functional p53. Phase 1.
Technical Data:
M.W. 328.41
Formula: <p>C<sub>21</sub>H<sub>20</sub>N<sub>4</sub></p>
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 881202-45-5
References:
References Kojima K, et al. Mol Cancer Ther. 2010, 9(9), 2545-2557. Yuan Y, et al. J Hematol Oncol. 2011, 4:16. Chargari C, et al. Cancer Lett. 2011, 312(2), 209-218. Smith MA, et al. Pediatr Blood Cancer, 2012, 59(2), 329-332.

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