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Purmorphamine

Purmorphamine

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Product Code: 9790
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An activator of the hedgehog signaling pathway.

 

Chemical Name: 2-(1-Naphthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine; 9-cyclohexyl-N-[4-(morpholinyl)phenyl]-2-(1-naphthalenyloxy)-9H-purin-6-amine

Purmorphamine Purines Hedgehog Signaling Pathway stem cell tissue regeneration 483367-10-8
Biological Activity:
Biological Activity Purmorphamine, a purine derivative, has been shown to activate the Hedgehog (Hh) signaling pathway which is important for regulating embryonic patterning, stem cell renewal, and tissue regeneration. Additionally, this compound has been noted to display osteogenesis-inducing activity in multipotent mesenchymal progenitor cells. Similar studies have reported Purmorphamine to enhance events related to osteoblast differentiation. Purmorphamine is an activator of Smo.
Technical Data:
M.W. 520.62
Formula: C<sub>31</sub>H<sub>32</sub>N<sub>6</sub>O<sub>2</sub>
Solubility: Soluble in DMSO (10 mM), DMF (~20 mg/ml), DMF:PBS(pH 7.2) (1:1) (~0.25 mg/ml)
Storage: Store at -20° C
CAS No: 483367-10-8
References:
References 1. Cooper, M.K., et al. 1998. Science. 280: 1603-1607. PMID: 9616123 2. Wu, X., et al. 2004. Chem. Biol. 11: 1229-1238. PMID: 15380183 3. Beachy, P.A., et al. 2004. Nature. 432: 324-331. PMID: 15549094 4. Beloti, M.M., et al. 2005. Cell Biol. Int. 29: 537-541. PMID: 15979909 5. Sinha, S. and Chen, J.K. 2006. Nat. Chem. Biol. 2: 29-30. PMID: 16408088

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