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EPZ-6438

EPZ-6438

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Product Code: 3136
Availability: In Stock
$243.00
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EPZ-6438 is a potent, and selective EZH2 inhibitor with Kiand IC50 of 2.5 nM and 11 nM, exhibiting a 35-fold selectivity versus EZH1 and >4,500-fold selectivity relative to 14 other HMTs.

Chemical Name [1,1'-Biphenyl]-3-carboxamide, N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-5-[ethyl(tetrahydro-2H-pyran-4-yl)amino]-4-methyl-4'-(4-morpholinylmethyl)-

 

Inhibitors Epigenetics Histone Methyltransferase EPZ-6438 1403254-99-8
Biological Activity:
Biological Activity EPZ-6438 is a potent, and selective EZH2 inhibitor with Ki and IC50 of 2.5 nM and 11 nM, exhibiting a 35-fold selectivity versus EZH1 and >4,500-fold selectivity relative to 14 other HMTs.
Technical Data:
M.W. 572.74
Formula: C<sub>34</sub>H<sub>44</sub>N<sub>4</sub>O<sub>4</sub>
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 1403254-99-8
References:
References Knutson SK, et al. Proc Natl Acad Sci U S A. 2013, 110(19), 7922-7927. Johnston LD, et al. ASH Annual Meeting Abstracts. 2013.

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