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SGC 0946

SGC 0946

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Product Code: 3258
Availability: In Stock
$259.00
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SGC 0946 is a highly potent and selective DOT1Lmethyltransferase inhibitor with IC50 of 0.3 nM, is inactive against a panel of 12 PMTs and DNMT1.

Chemical Name:
1-[3-[[[(2R,3S,4R,5R)-5-(4-Amino-5--bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydro-xytetrahydrofuran-2-yl]methyl](isopropyl)amino]pro-pyl]-3-[4-(2,2-dimethylethyl)phenyl]urea

Inhibitors Epigenetics Histone Methyltransferase SGC 0946
Biological Activity:
Biological Activity SGC 0946 is a highly potent and selective DOT1L methyltransferase inhibitor with IC50 of 0.3 nM, is inactive against a panel of 12 PMTs and DNMT1.
Technical Data:
M.W. 618.57
Formula: C<sub>28</sub>H<sub>40</sub>BrN<sub>7</sub>O<sub>4</sub>
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No:
References:
References Yu W, et al. Nat Commun, 2012, 3, 1288.

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