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IOX2

IOX2

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Product Code: 3422
Availability: In Stock
$180.00
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IOX2 is a potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) with IC50 of 21 nM, >100-fold selectivity over JMJD2A, JMJD2C, JMJD2E, JMJD3, or the 2OG oxygenase FIH.

Chemical Name Glycine, N-[[1,2-dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]-

Inhibitors Epigenetics HIF IOX2 931398-72-0
Biological Activity:
Biological Activity IOX2 is a potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) with IC50 of 21 nM, >100-fold selectivity over JMJD2A, JMJD2C, JMJD2E, JMJD3, or the 2OG oxygenase FIH.
Technical Data:
M.W. 352.34
Formula: <p>C<sub>19</sub>H<sub>16</sub>N<sub>2</sub>O<sub>5</sub></p>
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 931398-72-0
References:
References Murray JK, et al. J Comb Chem, 2010, 12(5), 676-686. Tian YM, et al. J Biol Chem, 2011, 286(15), 13041-13051.

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