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SGI-1776 free base

SGI-1776 free base

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Product Code: 3255
Availability: In Stock
$335.00
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SGI-1776 is a novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM, 50- and 10-fold selective versus Pim2 and Pim3, also potent to Flt3 and haspin. Phase 1.

Chemical Name:
N-((1-methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine

Inhibitors JAK/STAT Pim SGI-1776 free base 1025065-69-3
Biological Activity:
Biological Activity SGI-1776 is a novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM, 50- and 10-fold selective versus Pim2 and Pim3, also potent to Flt3 and haspin. Phase 1.
Technical Data:
M.W. 405.42
Formula: C<sub>20</sub>H<sub>22</sub>F<sub>3</sub>N<sub>5</sub>O
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 1025065-69-3
References:
References Chen LS, et al. Blood, 2011, 118(3), 693-702. Chen LS, et al. Blood, 2009, 114(19), 4150-7. Batra V, et al. Pediatr Blood Cancer, 2012, 59(4), 749-752.

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