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Rucaparib

Rucaparib

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Product Code: 3273
Availability: In Stock
$259.00
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Rucaparib (AG-014699, PF-01367338) is an inhibitor of PARP with Ki of 1.4 nM for PARP1, also showing binding affinity to eight other PARP domains. Phase 1/2.

Chemical Name:
8-fluoro-5-(4-((methylamino)methyl)phenyl)-3,4-dihydro-2H-azepino[5,4,3-cd]indol-1(6H)-one phosphoric acid

Inhibitors > Epigenetics > PARP Rucaparib 459868-92-9
Biological Activity:
Biological Activity Rucaparib (AG-014699, PF-01367338) is an inhibitor of PARP with Ki of 1.4 nM for PARP1, also showing binding affinity to eight other PARP domains. Phase 1/2.
Technical Data:
M.W. 421.36
Formula: C<sub>19</sub>H<sub>18</sub>FN<sub>3</sub>O.H<sub>3</sub>PO<sub>4</sub>
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 459868-92-9
References:
References Thomas HD, et al. Mol Cancer Ther, 2007, 6(3), 945-956. Kotz, J. SciBX 5(13); doi:10.1038/scibx.2012.323. Hunter JE, et al. Oncogene, 2012, 31(2), 251-264. Daniel RA, et al. Br J Cancer, 2010, 103(10), 1588-1596. Daniel RA, et al. Clin Cancer Res, 2009, 15(4), 1241-1249.

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