Topotecan HCl

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Product Code: 3206
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Topotecan (NSC 609699) is a topoisomerase I inhibitor for MCF-7 Luc cells and DU-145 Luc cells with IC50 of 13 nM and 2 nM, respectively.

Chemical Name:
1-[5-[(2,3-Dichlorophenyl)thio]-4-nitro-2-thienyl]ethanone

Biological Activity:
Biological Activity	Topotecan (NSC 609699) is a topoisomerase I inhibitor for MCF-7 Luc cells and DU-145 Luc cells with IC50 of 13 nM and 2 nM, respectively.
Technical Data:
M.W.	457.91
Formula:	C<sub>23</sub>H<sub>23</sub>N<sub>3</sub>O<sub>5</sub>.HCl
Solubility:	DMSO
Purity:	98%
Storage:	-20℃
CAS No:	119413-54-6
References:
References	Caceres G, et al. Anticancer Drugs. 2003, 14(7), 569-574. Uckun FM, et al. Blood. 1995. 85(10), 2817-2828. Ciusani E, et al. J Neurooncol. 2005, 71(1), 19-25. McCluskey AG, et al. J Nucl Med. 2012, 53(7), 1146-1154. Romanelli S, et al. Cancer Chemother Pharmacol. 1998, 41(5), 385-390.

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