eIF4E/eIF4G Interaction Inhibitor, 4EGI-1

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Product Code: 9789
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An inhibitor of cap-dependent protein translation.

Chemical Name: α-[2-[4-(3,4-Dichlorophenyl)-2-thiazolyl]hydrazinylidene]-2-nitro-benzenepropanoic acid

Biological Activity:
Biological Activity	eIF4E/eIF4G Interaction Inhibitor, 4EGI-1, has been shown to amplify TRAIL (tumor necrosis factor-related apoptosis-inducing ligand)-induced apoptosis via down-regulation of FLIPS/L and induction of DR5. These characteristics of the compound seem to be independent of it's ability to inhibit cap-dependent protein translation which is caused by disruption of the eIF4E/eIF4G association through binding to eIF4E. It has been shown that while 4EGI-1 displaces eIF4G from eIF4E, it consequentially enhances 4E-BP association both in vivo and in vitro. 4E-BPs regulated the eIF4E/eIF4G complex which has a central role in the regulation of gene expression at the level of translation initiation.
Technical Data:
M.W.	451.3
Formula:	C<sub>18</sub>H<sub>12</sub>C<sub>12</sub>N<sub>4</sub>O<sub>4</sub>S
Solubility:	Soluble to 100 mM in DMSO
Storage:	Store at -20°C
CAS No:	315706-13-9
References:
References	1. Moerke, N.J., et al. 2007. Cell. 128: 257-267. PMID: 17254965 2. Carroll, M. 2009. Blood. 114: 1458-1459. PMID: 19696209 3. Tamburini, J., et al. 2009. Cell Cycle. 8: 3893-3899. PMID: 19934662 4. Fan, S., et al. 2010. Neoplasia. 12: 346-356. PMID: 20360945

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