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Dinaciclib

Dinaciclib

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Product Code: 3117
Availability: In Stock
$587.00
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Dinaciclib (SCH727965) is a novel and potent CDK inhibitor for CDK2, CDK5, CDK1 and CDK9 with IC50 of 1 nM, 1 nM, 3 nM and 4 nM, respectively. It also blocks thymidine (dThd) DNA incorporation. Phase 3.

Chemical Name

(S)-3-(((3-ethyl-5-(2-(2-hydroxyethyl)piperidin-1-yl)pyrazolo[1,5-a]pyrimidin-7-yl)amino)methyl)pyridine 1-oxide

Inhibitors Cell Cycle CDK Dinaciclib 779353-01-4
Biological Activity:
Biological Activity Dinaciclib (SCH727965) is a novel and potent CDK inhibitor for CDK2, CDK5, CDK1 and CDK9 with IC50 of 1 nM, 1 nM, 3 nM and 4 nM, respectively. It also blocks thymidine (dThd) DNA incorporation. Phase 3.
Technical Data:
M.W. 396.49
Formula: C<sub>21</sub>H<sub>28</sub>N<sub>6</sub>O<sub>2</sub>
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 779353-01-4
References:
References Parry D, et al. Mol Cancer Ther. 2010, 9(8), 2344-2453. Guzi TJ, et al. Mol Cancer Ther. 2011, 10(4), 591-602. Abdullah C, et al. Cell Cycle. 2011, 10(6), 977-988. Fu W, et al. Mol Cancer Ther. 2011, 10(6), 1018-1027.

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