JNK Inhibitor VIII

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Product Code: 9779
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An inhibitor shown to suppress apoptosis, caspase cleavage, and cytochrome C release.

Chemical Name: N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxyphenyl)acetamide

Biological Activity:
Biological Activity	JNK inhibitor VIII is an inhibitor of JNK (c-Jun N-terminal kinases) that has been reported to suppress apoptosis, caspase cleavage, and cytochrome C release. Studies indicate that the inhibitor can block the phosphorylation of JNK without affecting the expression of IL-6, IL-8, or COX-2. JNK activity studies demonstrate that JNK Inhibitor VIII inhibits the phosphorylation of JNKAR1 and response to Anisomycin. Additionally, JNK Inhibitor VIII has been noted to reduce TGF-induced JNK activation. JNK Inhibitor VIII is an inhibitor of JNK1, JNK2 and JNK3.
Technical Data:
M.W.	356.4
Formula:	C<sub>18</sub>H<sub>20</sub>N<sub>4</sub>O<sub>4</sub>
Solubility:	Soluble in DMSO (100 mM).
Storage:	Store at -20° C
CAS No:	894804-07-0
References:
References	1. Ogino, T., et al. 2009. Leuk. Res. 33: 151-158. PMID: 18718660 2. Kluwe, J., et al. 2010. Gastroenterology. 138: 347-359. PMID: 19782079 3. Turpeinen, T., et al. 2010. J. Pharmacol. Exp. Ther. 333: 310-318. PMID: 20089808 4. Fosbrink, M., et al. 2010. Proc. Natl. Acad. Sci. U.S.A. 107: 5459-5464. PMID: 20212108

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