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SP600125

SP600125

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Product Code: 3243
Availability: In Stock
$180.00
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SP600125 is a broad-spectrum JNK inhibitor for JNK1, JNK2 and JNK3 with IC50 of 40 nM, 40 nM and 90 nM, respectively; 10-fold greater selectivity against MKK4, 25-fold greater selectivity against MKK3, MKK6, PKB, and PKCα, and 100-fold selectivity against ERK2, p38, Chk1, EGFR etc.

Chemical Name:
2H-Dibenzo[cd,g]indazol-6-one

Inhibitors MAPK JNK SP600125 129-56-6
Biological Activity:
Biological Activity SP600125 is a broad-spectrum JNK inhibitor for JNK1, JNK2 and JNK3 with IC50 of 40 nM, 40 nM and 90 nM, respectively; 10-fold greater selectivity against MKK4, 25-fold greater selectivity against MKK3, MKK6, PKB, and PKCα, and 100-fold selectivity against ERK2, p38, Chk1, EGFR etc.
Technical Data:
M.W. 220.23
Formula: C<sub>14</sub>H<sub>8</sub>N<sub>2</sub>O
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 129-56-6
References:
References Bennett BL, et al. Proc Natl Acad Sci U S A, 2001, 98(24), 13681-13686. Joiakim A, et al. Drug Metab Dispos, 2003, 31(11), 1279-1282. Schmidt M, et al. EMBO Rep, 2005, 6(9), 866-872. Colombo R, et al. Cancer Res, 2010, 70(24), 10255-64. Vaishnav D, et al. Biochem Biophys Res Commun, 2003, 307(4), 855-860. Kim JA, et al. Oncogene, 2010, 29(11), 1702-1716.

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