JAK Inhibitor I

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Product Code: 9716
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JAK Inhibitor I is a potent, reversible, cell-permeable, and ATP-competitive inhibitor of JAK1, JAK2, and JAK3

Synonym
Synonym	Pyridone 6; 2-(1,1-Dimethylethyl)-9-fluoro-3,6-dihydro-7H-benz[h]-imidaz[4,5-f]isoquinolin-7-one
Chemical Name:
Chemical Name	2-(1,1-Dimethylethyl)-9-fluoro-3,6-dihydro-7H-benz[h]-imidaz[4,5-f]isoquinolin-7-one
Biological Activity:
Biological Activity	Primary target: murine JAK1. JAK1 (Janus kinase 1), JAK2 and JAK3 belong to the family of non-receptor janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of STAT transcription factors to cytokine receptor-associated JAK1, JAK2 and JAK3.
Technical Data:
M.W.	309.34
Formula:	C<sub>18</sub>H<sub>16</sub>FN<sub>3</sub>O
Solubility:	Soluble in DMSO (5 mg/ml).
CAS No:	457081-03-7
References:
References	1. Chi, X. and Tai, H.H. 2010. Exp. Cell Res. PMID: 20685602 2. Chrencik, J.E. et al. 2010. J. Mol. Biol. 400(3): 413-433. PMID: 20478313 3. Matsunaga, Y. et al. 2011. Biochem. Biophys. Res. Commun. 404(1): 261-267. PMID: 21111712 4. Nakagawa, R. et al. 2011. J. Immunol. 187(9): 4611-4620. PMID: 21957150

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