Tofacitinib

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Product Code: 3211
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Tofacitinib citrate (CP-690550 citrate) is a novel inhibitor of JAK3 with IC50 of 1 nM, 20- to 100-fold less potent against JAK2 and JAK1.

Chemical Name:
3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile citrate

Biological Activity:
Biological Activity	Tofacitinib citrate (CP-690550 citrate) is a novel inhibitor of JAK3 with IC50 of 1 nM, 20- to 100-fold less potent against JAK2 and JAK1.
Technical Data:
M.W.	504.49
Formula:	C<sub>16</sub>H<sub>20</sub>N<sub>6</sub>O.C<sub>6</sub>H<sub>8</sub>O<sub>7</sub>
Solubility:	DMSO
Purity:	98%
Storage:	-20℃
CAS No:	540737-29-9
References:
References	Flanagan ME, et al. J Med Chem, 2010, 53(24), 8468-8484. Manshouri T, et al. Cancer Sci, 2008, 99(6), 1265-1273. Conklyn M, et al. J Leukoc Biol, 2004, 76(6), 1248-1255.

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