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NSC 207895

NSC 207895

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Product Code: 3348
Availability: In Stock
$398.00
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NSC 207895 suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.

Chemical Name 2,1,3-Benzoxadiazole, 4-(4-methyl-1-piperazinyl)-7-nitro-, 3-oxide

Inhibitors Apoptosis Mdm2 NSC 207895 58131-57-0
Biological Activity:
Biological Activity NSC 207895 suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.
Technical Data:
M.W. 279.25
Formula: <p>C<sub>11</sub>H<sub>13</sub>N<sub>5</sub>O<sub>4</sub></p>
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 58131-57-0
References:
References Wang H, et al. Mol Cancer Ther, 2011, 10(1), 69-79. Kessel D, et al. Cancer Res, 1975, 35(12), 3735-3740. Kapitzky L, et al. Mol Syst Biol, 2010, 6, 451. Hawes JJ, et al. J Biomol Screen, 2008, 13(8), 795-803.

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