Pifithrin-α

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Product Code: 3310
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Pifithrin-α is an inhibitor of p53, inhibiting p53-dependent transactivation of p53-responsive genes.

Chemical Name Ethanone, 1-(4-methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)-, hydrobromide (1:1)

Biological Activity:
Biological Activity	Pifithrin-α is an inhibitor of p53, inhibiting p53-dependent transactivation of p53-responsive genes.
Technical Data:
M.W.	367.3
Formula:	<p>C<sub>16</sub>H<sub>18</sub>N<sub>2</sub>OS.HBr</p>
Solubility:	DMSO
Purity:	98%
Storage:	-20℃
CAS No:	63208-82-2
References:
References	Komarov PG, et al. Science, 1999, 285(5434), 1733-1737. Culmsee C, et al. J Neurochem, 2001, 77(1), 220-228. Komarova EA, et al. J Biol Chem, 2003, 278(18), 15465-15468. Murphy PJ, et al. J Biol Chem, 2004, 279(29), 30195-301201. Leker RR, et al. Exp Neurol, 2004, 187(2), 478-486.

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