AVL-292

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Product Code: 3041
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AVL-292 is a covalent, orally active, and highly selective BTK inhibitor with IC50 of <0.5 nM, displaying at least 1400-fold selectivity over the other kinases assayed. Phase 1.

Chemical Name: 2-Propenamide, N-[3-[[5-fluoro-2-[[4-(2-methoxyethoxy)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-

Biological Activity:
Biological Activity	Evans E, et al. ASH Annual Meeting, 2011 San Diego, CA. Evans EK, et al. J Pharmacol Exp Ther. 2013, 346(2), 219-228.
Technical Data:
M.W.	423.44
Formula:	C<sub>22</sub>H<sub>22</sub>FN<sub>5</sub>O<sub>3</sub>
Solubility:	DMSO
Purity:	98%
Storage:	-20℃
CAS No:	1202757-89-8

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AVL-292

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