Saracatinib

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Product Code: 3265
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Saracatinib (AZD0530) is a potent Src inhibitor with IC50 of 2.7 nM, and potent to c-Yes, Fyn, Lyn, Blk, Fgr and Lck; less active for Abl and EGFR (L858R and L861Q). Phase 1/2.

Chemical Name:
N-(5-chlorobenzo[d][1,3]dioxol-4-yl)-7-(2-(4-methylpiperazin-1-yl)ethoxy)-5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine

Biological Activity:
Biological Activity	Saracatinib (AZD0530) is a potent Src inhibitor with IC50 of 2.7 nM, and potent to c-Yes, Fyn, Lyn, Blk, Fgr and Lck; less active for Abl and EGFR (L858R and L861Q). Phase 1/2.
Technical Data:
M.W.	542.03
Formula:	C<sub>27</sub>H<sub>32</sub>ClN<sub>5</sub>O<sub>5</sub>
Solubility:	DMSO
Purity:	98%
Storage:	-20℃
CAS No:	379231-04-6
References:
References	Chang YM, Oncogene, 2008, 27(49), 6365-6375. Green TP, et al. Mol Oncol, 2009, 3(3), 248-261. Purnell PR, et al. J Thorac Oncol, 2009, 4(4), 448-454. de Vries TJ, et al. Mol Cancer Res, 2009, 7(4), 476-488. Gwanmesia PM, et al. BMC Cancer, 2009, 13;9:53. Hiscox S, et al. Breast Cancer Res Treat, 2009, 115(1), 57-67. Chen Y, et al. Clin Cancer Res, 2009, 15(10), 3396-3405.

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Saracatinib

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