2-Methoxyestradiol

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Product Code: 3001
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2-Methoxyestradiol depolymerizes microtubules and blocks HIF-1α nuclear accumulation and HIF-transcriptional activity. Phase 2.

Chemical Name (8R,9S,13S,14S,17S)-2-methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol

Biological Activity:
Biological Activity	2-Methoxyestradiol depolymerizes microtubules and blocks HIF-1α nuclear accumulation and HIF-transcriptional activity. Phase 2.
Technical Data:
M.W.	302.41
Formula:	<h1> C<sub>19</sub>H<sub>26</sub>O<sub>3</sub></h1>
Solubility:	DMSO
Purity:	98%
Storage:	-20℃
CAS No:	362-07-2
References:
References	Rao PN, et al. Steroids. 2002, 67(13-14), 1079-1089. Seeger H, et al. J Steroid Biochem Mol Biol. 2003, 84(2-3), 255-257. Mabjeesh NJ, et al. Cancer Cell. 2003, 3(4), 363-375. Salama SA, et al. Fertil Steril. 2012. Kang SH, et al. Cancer Res. 2006, 66(24),11991-11997. Fotopoulou C, et al. Anticancer Res. 2010, 30(11), 4619-4624.

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