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AZD8931

AZD8931

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Product Code: 3048
Availability: In Stock
$398.00
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AZD8931 is a reversible, ATP competitive inhibitor of EGFR, ErbB2 and ErbB3 with IC50 of 4 nM, 3 nM and 4 nM, more potent than Gefitinib or Lapatinib against NSCLC cell, 100-fold more selective for the ErbB family than MNK1 and Flt. Phase 1/2.

Chemical Name: 2-(4-(4-(3-chloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)piperidin-1-yl)-N-methylacetamide

Inhibitors Angiogenesis HER2 AZD8931 848942-61-0
Biological Activity:
Biological Activity AZD8931 is a reversible, ATP competitive inhibitor of EGFR, ErbB2 and ErbB3 with IC50 of 4 nM, 3 nM and 4 nM, more potent than Gefitinib or Lapatinib against NSCLC cell, 100-fold more selective for the ErbB family than MNK1 and Flt. Phase 1/2.
Technical Data:
M.W. 473.93
Formula: C<sub>23</sub>H<sub>25</sub>ClFN<sub>5</sub>O<sub>3</sub>
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 848942-61-0
References:
References Hickinson DM, et al. Clin Cancer Res, 2010, 16(4), 1159-1169.

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