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Neratinib

Neratinib

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Product Code: 3325
Availability: In Stock
$587.00
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Neratinib (HKI-272) is a highly selective HER2 and EGFR inhibitor with IC50 of 59 nM and 92 nM; weakly inhibits KDR and Src, no significant inhibition to Akt, CDK1/2/4, IKK-2, MK-2, PDK1, c-Raf and c-Met. Phase 3.

Chemical Name (E)-N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide

 

Inhibitors Angiogenesis HER2 Neratinib 698387-09-6
Biological Activity:
Biological Activity Neratinib (HKI-272) is a highly selective HER2 and EGFR inhibitor with IC50 of 59 nM and 92 nM; weakly inhibits KDR and Src, no significant inhibition to Akt, CDK1/2/4, IKK-2, MK-2, PDK1, c-Raf and c-Met. Phase 3.
Technical Data:
M.W. 557.04
Formula: <p>C<sub>30</sub>H<sub>29</sub>ClN<sub>6</sub>O<sub>3</sub></p>
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 698387-09-6
References:
References Rabindran SK, et al. Cancer Res, 2004, 64(11), 3958-3965.

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