BMS-777607

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Product Code: 3072
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BMS-777607 is a Met-related inhibitor for c-Met, Axl, Ron and Tyro3 with IC50 of 3.9 nM, 1.1 nM, 1.8 nM and 4.3 nM, 40-fold more selective for Met-related targets versus Lck, VEGFR-2, and TrkA/B, and more than 500-fold greater selectivity versus all other receptor and non receptor kinases. Phase 1/2.

Chemical Name N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Biological Activity:
Biological Activity	BMS-777607 is a Met-related inhibitor for c-Met, Axl, Ron and Tyro3 with IC50 of 3.9 nM, 1.1 nM, 1.8 nM and 4.3 nM, 40-fold more selective for Met-related targets versus Lck, VEGFR-2, and TrkA/B, and more than 500-fold greater selectivity versus all other receptor and non receptor kinases. Phase 1/2.
Technical Data:
M.W.	512.89
Formula:	<p>C<sub>25</sub>H<sub>19</sub>ClF<sub>2</sub>N<sub>4</sub>O<sub>4</sub></p>
Solubility:	DMSO
Purity:	98%
Storage:	-20℃
CAS No:	1025720-94-8
References:
References	Schroeder GM, et al. J Med Chem, 2009, 52(5), 1251-1254. Dai Y, et al. Mol Cancer Ther, 2010, 9(6), 1554-1561. Dai Y, et al. Clin Exp Metastasis, 2012, 29, 253-261. Kim KS, et al. J Med Chem, 2008, 51(17), 5330-5341.

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BMS-777607

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