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R428

R428

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Product Code: 3293
Availability: In Stock
$1,721.00
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R428 is an inhibitor of Axl with IC50 of 14 nM, >100-fold selective for Axl versus Abl. Selectivty for Axl is also greater than Mer and Tyro3 (50-to-100- fold more selective) and InsR, EGFR, HER2, and PDGFRβ (100- fold more selective).

Chemical Name 1H-1,2,4-Triazole-3,5-diamine, 1-(6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3-yl)-N3-[(7S)-6,7,8,9-tetrahydro-7-(1-pyrrolidinyl)-5H-benzocyclohepten-2-yl]-

Inhibitors Protein Tyrosine Kinase AxI R428 1037624-75-1
Biological Activity:
Biological Activity R428 is an inhibitor of Axl with IC50 of 14 nM, >100-fold selective for Axl versus Abl. Selectivty for Axl is also greater than Mer and Tyro3 (50-to-100- fold more selective) and InsR, EGFR, HER2, and PDGFRβ (100- fold more selective).
Technical Data:
M.W. 506.64
Formula: <p>C<sub>30</sub>H<sub>34</sub>N<sub>8</sub></p>
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 1037624-75-1
References:
References Holland SJ, et al. Cancer Res, 2010, 70(4), 1544-1554. Ghosh AK, et al. Blood, 2011, 117(6), 1928-1937.

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