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BMS-754807

BMS-754807

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Product Code: 3071
Availability: In Stock
$335.00
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BMS-754807 is a potent and reversible inhibitor of IGF-1R/InsR with IC50 of 1.8 nM/1.7 nM, less potent to Met, Aurora A/B, TrkA/B and Ron, and shows little activity to Flt3, Lck, MK2, PKA, PKC etc. Phase 1/2.

Chemical Name (S)-1-(4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrrolo[1,2-f][1,2,4]triazin-2-yl)-N-(6-fluoropyridin-3-yl)-2-methylpyrrolidine-2-carboxamide

 

Inhibitors Protein Tyrosine Kinase Trk receptor BMS-754807 1001350-96-4
Biological Activity:
Biological Activity BMS-754807 is a potent and reversible inhibitor of IGF-1R/InsR with IC50 of 1.8 nM/1.7 nM, less potent to Met, Aurora A/B, TrkA/B and Ron, and shows little activity to Flt3, Lck, MK2, PKA, PKC etc. Phase 1/2.
Technical Data:
M.W. 461.49
Formula: <p>C<sub>23</sub>H<sub>24</sub>FN<sub>9</sub>O</p>
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 1001350-96-4
References:
References Carboni JM, et al. Mol Cancer Ther, 2009, 8(12), 3341-3349. Wittman MD, et al. J Med Chem, 2009, 52(23), 7360-7363. Kolb EA, et al. Pediatr Blood Cancer, 2011, 56(4), 595-603.

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