AP26113

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Product Code: 10422
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AP26113 is a potent and selective active inhibitor of anaplastic lymphoma kinase(ALK) with IC50 of 0.62 nM

Biological Activity:
Biological Activity	AP26113 is a potent and selective active inhibitor of anaplastic lymphoma kinase(ALK) with IC50 of 0.62 nM. IC50 Value: 0.62 nM (ALK); 30.8 nM (Growth inhibition of EML4-ALK or NPM-ALK positive NSCLC and ALCL cell lines) [1] Target: ALK
Technical Data:
M.W.	529.01
Formula:	C<sub>26</sub>H<sub>34</sub>ClN<sub>6</sub>O<sub>2</sub>P
Solubility:	DMSO 45 mg/mL; Water <1 mg/mL; Ethanol 106 mg/mL
CAS No:	1197958-12-5
References:
References	[1]. Rivera V M, Anjum R, Wang F, Efficacy and pharmacodynamic analysis of AP26113, a potent and selective orally active inhibitor of anaplastic lymphoma kinase (ALK). Proc.Am.Assoc.Cancer Res., 2010, 51, Abs3623 [2]. Sen Zhang, Frank Wang, Jeffrey Keats, Abstract LB-298: AP26113, a potent ALK inhibitor, overcomes mutations in EML4-ALK that confer resistance to PF-02341066 (PF1066). Cancer Research: April 15, 2010; Volume 70, Issue 8, Supplement 1 [3]. Victor M. Rivera, Frank Wang, Rana Anjum, Abstract 1794: AP26113 is a dual ALK/EGFR inhibitor: Characterization against EGFR T790M in cell and mouse models of NSCLC. Cancer Research: April 15, 2012; Volume 72, Issue 8, Supplement 1

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