Masitinib

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Product Code: 3385
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Masitinib is a novel inhibitor for Kit and PDGFRα/β with IC50 of 200 nM and 540 nM/800 nM, weak inhibition to ABL and c-Fms. Phase 2/3.

Chemical Name N-(4-methyl-3-(4-(pyridin-3-yl)thiazol-2-ylamino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide

Biological Activity:
Biological Activity	Masitinib is a novel inhibitor for Kit and PDGFRα/β with IC50 of 200 nM and 540 nM/800 nM, weak inhibition to ABL and c-Fms. Phase 2/3.
Technical Data:
M.W.	498.64
Formula:	<p>C<sub>28</sub>H<sub>30</sub>N<sub>6</sub>OS</p>
Solubility:	DMSO
Purity:	98%
Storage:	-20℃
CAS No:	790299-79-5
References:
References	Dubreuil P, et al. PLoS One, 2009, 4(9), e7258. Lawrence J, et al. Vet Comp Oncol, 2011, doi: 10.1111/j.1476-5829.2011.00291.x. Hahn KA, et al. J Vet Intern Med, 2008, 22(6), 1301-1309. Humbert M, et al. PLoS One, 2010, 5(3), e9430.

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