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PF-4708671

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Product Code: 3358
Availability: In Stock
$180.00
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PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) with Ki/IC50 of 20 nM/160 nM, 400-fold greater selectivity for S6K1 than S6K2, and 4- and >20-fold selectivity for S6K1 than MSK1 and RSK1/2, respectively. First S6K1-specific inhibitor to be reported.

Chemical Name 1H-Benzimidazole, 2-[[4-(5-ethyl-4-pyrimidinyl)-1-piperazinyl]methyl]-6-(trifluoromethyl)-

Inhibitors PI3K/Akt/mTOR S6 Kinase PF-4708671 1255517-76-0
Biological Activity:
Biological Activity PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) with Ki/IC50 of 20 nM/160 nM, 400-fold greater selectivity for S6K1 than S6K2, and 4- and >20-fold selectivity for S6K1 than MSK1 and RSK1/2, respectively. First S6K1-specific inhibitor to be reported.
Technical Data:
M.W. 390.41
Formula: <p>C<sub>19</sub>H<sub>21</sub>F<sub>3</sub>N<sub>6</sub></p>
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 1255517-76-0
References:
References Pearce LR, et al. Biochem J, 2010, 431(2), 245-255.

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