GSK-3 Inhibitor II

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Product Code: 9782
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GSK-3 Inhibitor II is a potent inhibitor of GSK-3β (glycogen synthase kinase-3β) (IC₅₀=390 nM).

Chemical Name: TIBPO; 2-Thio(3-iodobenzyl)-5-(1-pyridyl)-[1,3,4]-oxadiazole

Biological Activity:
Biological Activity	GSK-3 Inhibitor II is a potent inhibitor of GSK-3β (glycogen synthase kinase-3β) (IC50=390 nM). GSK-3 was first discovered to be involved in the control of glycogen metabolism, but has since been indicated in regulating a diverse range of cellular functions, such as neuronal cell survival and death.
Technical Data:
M.W.	395.2
Formula:	<p>C<sub>14</sub>H<sub>10</sub>IN<sub>3</sub>OS</p>
Solubility:	DMSO
Storage:	Store at -20° C
CAS No:	478482-75-6
References:
References	1. Koh, S.H., et al. 2005. Eur. J. Neurosci. 22: 301-309. PMID: 16045483 2. Seng, S., et al. 2006. Mol. Cell. Biol. 26: 8371-8384. PMID: 16982692 3. Wang, Y., et al. 2009. Diabetes. 58: 1391-1402. PMID: 19324938 4. Gimenez-Cassina, A., et al. 2009. J. Biol. Chem. 284: 3001-3011. PMID: 19033437 5. Severson, E.A., et al. 2010. Biochem Biophys Res Commun. PMID: 20685350 6. Webb, I.G., et al. 2010. J Mol Cell Cardiol. PMID: 20696171

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