Rapamycin

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Product Code: 3288
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Rapamycin (Sirolimus, AY-22989, WY-090217) is a specific mTOR inhibitor with IC50 of ~0.1 nM.

Chemical Name (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone

Biological Activity:
Biological Activity	Rapamycin (Sirolimus, AY-22989, WY-090217) is a specific mTOR inhibitor with IC50 of ~0.1 nM.
Technical Data:
M.W.	914.18
Formula:	<p>C<sub>51</sub>H<sub>79</sub>NO<sub>13</sub></p>
Solubility:	DMSO
Purity:	98%
Storage:	-20℃
CAS No:	53123-88-9
References:
References	Edwards SR, et al. J Biol Chem, 2007, 282(18), 13395-13401. Barbet NC, et al. Mol Biol Cell, 1996, 7(1), 25-42. Takeuchi H, et al. Cancer Res, 2005, 65(8), 3336-3346. Bodine SC, et al. Nat Cell Biol, 2001, 3(11), 1014-1019. Kenerson HL, et al. Cancer Res, 2002, 62(20), 5645-5650. Guba M, et al. Nat Med, 2002, 8(2), 128-135. Phung TL, et al. Cancer Cell, 2006, 10(2), 159-170. MG Mohi, et al. Proc Natl Acad Sci U S A, 2004, 101(9), 3130–3135.

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Rapamycin

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