PKR Inihibitor

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Product Code: 9781
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An RNA-dependent protein kinase inhibitor, PKR inhibitor may protect cells against ER stress induced cell damage.

Chemical Name: 8-(1H-Imidazol-5-ylmethylidene)-6,8-dihydro-7H-[1,3]thiazolo[5,4-e]indol-7-one

Biological Activity:
Biological Activity	PKR Inhibitor is an imidazolo-oxindole derivative that has been shown to inhibit RNA-induced PKR autophosphorylation and rescue PKR-dependent translation block. The alpha subunit of the eukaryotic initiation factor 2 is phosphorylated by the PKR, which is an interferon-induced serine/threonine protein. PKR influences cytokine gene expression stimulated by the latent membrane protein 1 (LMP) in Epstein-Barr virus. Research shows that PKR inhibitor inhibits the activities of caspase-3 and caspase-8 and prevents increase in pT(451)-PKR and pS(194)-FADD levels in SH-SY5Y nuclei
Technical Data:
M.W.	268.3
Formula:	C<sub>13</sub>H<sub>8</sub>N<sub>4</sub>OS
Solubility:	Soluble in DMSO (12 mg/ml).
Storage:	Store at 4° C
CAS No:	608512-97-6
References:
References	1. Jammi, N.V., et al. 2003. Biochem. Biophys. Res. Commun. 308: 50-57. PMID: 12890478 2. Shimazawa, M., et al. 2006. Neurosci. Lett. 409: 192-195. PMID: 17055645 3. Lin, S.S., et al. 2010. Cytokine. 50: 210-219. PMID: 20171114 4. Couturier, J., et al. 2010. J. Biol. Chem. 285: 1272-1282. PMID: 19889624

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