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Sitagliptin phosphate monohydrate

Sitagliptin phosphate monohydrate

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Product Code: 3253
Availability: In Stock
$108.00
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Sitagliptin phosphate is a potent inhibitor of DPP-IV with IC50 of 19 nM in Caco-2 cell extracts.

Chemical Name:
(R)-3-amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one phosphate monohydrate

 

Inhibitors Proteases DPP-4 Sitagliptin phosphate monohydrate 654671-77-9
Biological Activity:
Biological Activity Sitagliptin phosphate is a potent inhibitor of DPP-IV with IC50 of 19 nM in Caco-2 cell extracts.
Technical Data:
M.W. 523.32
Formula: C<sub>16</sub>H<sub>15</sub>F<sub>6</sub>N<sub>5</sub>O.H<sub>3</sub>PO<sub>4</sub>.H<sub>2</sub>O
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 654671-77-9
References:
References Thomas L et al. J Pharmacol Exp Ther. 2008; 325(1): 175-182. Kim SJ et al. Diabetes. 2009; 58(3): 641-651. Sangle GV et al. Endocrinology. 2012; 153(2): 564-573. Kim SJ et al. Diabetes. 2008; 57(5); 1331-1339. Beconi MG et al. Drug Metab Dispos.2007; 35(4): 525-532.

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